Editing CUA: RCC Genetic Screening (2013)

'''See [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854468/ Original Guideline]'''

'''*****All information below contained in more inclusive Kidney Cancer Chapter Notes'''

===== Criteria for referring patients with renal tumours for genetic assessment =====

# Patients with any renal tumour (benign or malignant) AND any one of the following:
## Bilaterality or multifocality
## Age of onset ≤45
## 1st or 2nd degree relative with any renal tumour
## A history of pneumothorax* (*or 1st degree relative with same) (found in BHDS)
## One of the following dermatologic findings:
### Skin leiomyomas* (found in HLRCC)
### Skin fibrofolliculomas/trichodisomas* (found in BHDS)
## One of the following associated tumours:
### Pheochromocytoma/paraganglioma*
### Hemangioblastoma of the retina, brainstem, cerebellum or spinal cord*
### Early onset of multiple uterine fibroids (<30 years of age)*
### Lymphangiomyomatosis*
### Childhood seizure disorder*
# Patients with non-clear cell carcinoma with unusual associated features (e.g., chromophobe, oncocytic or hybrid tumours)
# Patients, with or without RCC, who report a family member (any) with a known clinical or genetic diagnosis of any one of the following:
## Von Hippel-Lindau syndrome
## Hereditary papillary renal cell cancer
## Hereditary leiomyomatosis and renal cell cancer
## Birt-Hogg-Dubé syndrome
## Hereditary paraganglioma/pheochromocytoma
## Tuberous sclerosis