Editing Bladder (section)

=== Efferent ===
* '''The bladder wall is richly supplied with parasympathetic cholinergic nerve endings.'''
* '''Sparse sympathetic innervation of the bladder has been proposed to mediate detrusor relaxation''' but probably lacks functional significance
* Nitric oxide synthase–containing neurons have been identified in the detrusor, particularly at the bladder neck, where they facilitate relaxation during micturition.
* '''In males, the internal sphincter is richly innervated by adrenergic fibers, which act on α1-adrenergic receptors, and when stimulated, produce closure of the bladder neck.'''
** '''The internal sphincter is responsible for continence at the level of the bladder neck'''.
*** Perfect continence can be maintained in men in whom the striated urethral sphincter is destroyed, demonstrating the efficacy of this sphincter.
*** '''Damage to the sympathetic nerves leading to the bladder, as a result of diabetes mellitus or retroperitoneal lymph node dissection for testis cancer, can cause retrograde ejaculation'''.
* '''The female bladder neck has little adrenergic innervation.'''
* '''The trigonal muscle is innervated by adrenergic and nitric oxide synthase–containing neurons. Like the bladder neck, it relaxes during micturition.'''