Editing AUA: Early Detection of Prostate Cancer (2023) (section)

=== Role of prostate biopsy in very elevated PSA ===
*'''<span style="color:#ff0000">If PSA > 50 ng/mL </span>'''(and no clinical concerns for infection or other cause for increased PSA (e.g., recent prostate instrumentation)), '''<span style="color:#ff0000">may omit a prostate biopsy in cases if (2):</span>'''
*#'''<span style="color:#ff0000">Biopsy poses significant risk (e.g., anticoagulation, significant comorbidity, frailty)</span>'''
*#'''<span style="color:#ff0000">Need for prostate cancer treatment is urgent (e.g., impending spinal cord compression from metastases)</span>''' 
** Imaging to establish extent of disease or confirm metastasis may be helpful if an immediate biopsy is not performed.