Editing Pathophysiology of Erectile Dysfunction (section)

==== Neurogenic ====

* '''<span style="color:#ff0000">Any disease or dysfunction affecting the brain, spinal cord, and cavernous or pudendal nerves (Parkinson disease, stroke, encephalitis, temporal lobe epilepsy, tumors, dementias, Alzheimer disease, multiple system atrophy, trauma, spina bifida, disk herniation, syringomyelia, tumor, transverse myelitis, multiple sclerosis) can induce dysfunction</span>'''
* In men with a spinal cord injury, the nature, location (see Normal Erectile Physiology Chapter Notes), and extent of the injury largely determine erectile function. In addition to ED, these men may have impaired ejaculation and orgasm.
* '''Studies on sexual function in males with spina bifida have demonstrated that paternity is associated with an L5 or sacral neurologic level. This neurologic level was present in 80% of patients who fathered children.'''
* In '''diabetics''', impairment of neurogenic and endothelium-dependent relaxation results in '''inadequate NO release'''.
* Because autonomic penile innervation cannot be tested directly, '''clinicians should be cautious in diagnosing neurogenic ED.'''
* Sensory evaluation should be an integral part of the evaluation for ED in all patients with or without an apparent neurologic disorder