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Stones: Epidemiology and Pathogenesis
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=== Urine pH === * '''<span style="color:#ff0000">At low urine pH (<5.5), the undissociated form of uric acid predominates, leading to uric acid and/or calcium stone formation.</span>''' ** '''Any disorder leading to low urine pH may predispose to stone formation.''' ** '''Calcium oxalate stones can form in low urine pH as a result of heterogeneous nucleation with uric acid crystals'''. ** '''Chronic metabolic acidosis can lead to low urine pH, hypercalciuria, and hypocitraturia.'''
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