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Stones: Evaluation and Medical Management
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==== History ==== * '''Screen for factors that predispose to calculi''' ** '''<span style="color:#ff0000">Conditions associated with stone disease (8):</span>''' **#'''<span style="color:#ff0000">Obesity</span>''' **#'''<span style="color:#ff0000">Hyperthyroidism</span>''' **#'''<span style="color:#ff0000">Gout</span>''' **#'''<span style="color:#ff0000">Renal tubular acidosis (RTA) type 1</span>''' **#'''<span style="color:#ff0000">Diabetes mellitus type 2</span>''' **#'''<span style="color:#ff0000">Bone disease</span>''' **#'''<span style="color:#ff0000">Primary hyperparathyroidism</span>''' **#'''<span style="color:#ff0000">Malabsorptive gastrointestinal states</span>''' due to bowel resection, bariatric surgery or bowel or pancreatic disease **##'''Chronic diarrhea that could be caused by inflammatory bowel disease (Crohn disease, ulcerative colitis) or irritable bowel syndrome''' **## Gout may predispose the patient to hyperuricosuria or gouty diathesis with either uric acid calculi or calcium oxalate stone formers **## '''Surgical history should be obtained focusing particularly on bariatric surgery and surgeries of the intestinal tract.''' **###'''Roux-en-Y-gastric bypass surgery may significantly increase the overall risk for stone formation''' **###'''In contrast to gastric bypass surgery, restrictive bariatric surgeries such as gastric sleeve or gastric band do not seem to increase the risk for kidney stones''' **'''<span style="color:#ff0000">Dietary history</span>''' ***'''Should include average daily intake of fluids (amount and specific beverages), protein (types and amounts), calcium, sodium, high oxalate-containing foods, fruits and vegetables and over-the-counter supplements.''' **** '''Nutritional factors associated with stone disease, depending on stone type and risk factors, include''' *****Calcium intake below or significantly above the recommended dietary allowance (RDA) *****Low fluid intake *****High sodium intake *****Limited intake of fruits and vegetables *****High intake of animal-derived purines **'''<span style="color:#ff0000">Medications</span>''' ***'''Stone-provoking medications or supplements (9):''' ***#'''Probenecid''' ***#'''Some protease inhibitors''' ***#'''Lipase inhibitors''' ***#'''Triamterene''' ***#'''Chemotherapy''' ***#'''Vitamin C''' ***# '''Vitamin D''' ***#'''Calcium''' ***#'''Carbonic anhydrase inhibitors such as topiramate, acetazolamide, zonisamide'''
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