Editing Stones: Diet and Pharmacologic Management (section)

==== Allopurinol ====
*'''<span style="color:#ff0000">Should not be routinely offered as first-line therapy to patients with uric acid stones</span>'''
**'''Most patients with uric acid stones have low urinary pH rather than hyperuricosuria as the predominant risk factor'''
*'''<span style="color:#ff0000">May be considered as an adjunct when alkalinization is not successful or for patients who continue to form uric acid stones despite adequate alkalinization of the urine.</span>'''
*'''Dosage: allopurinol 300 mg/day may be used'''
**MOA: blocks the ability of xanthine oxidase to convert xanthine to uric acid, resulting in decreased production of uric acid
***The resultant decrease in serum uric acid will ultimately lead to a decrease in urinary uric acid as well.