Editing Biochemical Recurrence (section)

=== Natural history ===
* PSA-only recurrence after definitive radiation therapy for prostate cancer leads to clinically relevant outcomes such as local and distant failure along with cancer-specific death.
* Men with PSA elevation after definitive radiotherapy are candidates for salvage therapy
* '''Factors associated with clinical progression after biochemical recurrence after radiation terapy (4):'''
*# '''Time from radiation therapy to biochemical recurrence <3 years'''
*# '''PSA doubling time <3 months'''
*## '''PSA doubling time has consistently demonstrated the ability to predict for patients who are at highest risk for failure after radiotherapy''' and has been linked to freedom from biochemical recurrence, local relapse, distant metastasis, and overall survival.
*# '''Pretreatment biopsy grade group ≥4'''
*# '''Pretreatment clinical tumor stage ≥cT3b'''