Editing Management of Localized Prostate Cancer (section)

=== <span style="color:#ff0000">Contraindications</span> ===

*'''<span style="color:#0000ff">ST-LIAR</span> (<span style="color:#0000ff">S</span><span style="color:#ff0000">ize, </span><span style="color:#0000ff">T</span><span style="color:#ff0000">URP, </span><span style="color:#0000ff">L</span><span style="color:#ff0000">UTS, </span><span style="color:#0000ff">I</span><span style="color:#ff0000">BD, </span><span style="color:#0000ff">A</span><span style="color:#ff0000">taxia telangiectaisia, </span><span style="color:#0000ff">R</span><span style="color:#ff0000">adiation)[https://www.auanet.org/guidelines/archived-documents/prostate-cancer-clinically-localized-guideline]</span>'''
** '''<span style="color:#ff0000">Absolute (2)</span>'''
**# '''<span style="color:#ff0000">Prior </span><span style="color:#0000ff">T<span style="color:#ff0000">URP for brachytherapy if the TUR defect precludes adequate placement of seeds</span>''' (also associated with increased risk of stricture)
**#* Note that Campbell's considers prior TURP a relative contraindication for both brachytherapy and EBRT but the 2017 AUA Localized Prostate Cancer Guidelines describe the above contraindication)
**# '''<span style="color:#0000ff">A</span><span style="color:#ff0000">taxia telangiectasia</span>''' (severe response to ionizing radiation)
** '''<span style="color:#ff0000">Relative (4)</span>'''
**# '''<span style="color:#ff0000">Significant baseline <span style="color:#0000ff">L</span><span style="color:#ff0000">ower urinary tract voiding symptoms</span>''' (can cause acute urinary retention and worsen storage and voiding symptoms, '''risk increased with brachytherapy;''' on the other hand, radiotherapy can gradually relieve obstructive urinary symptoms in men with urinary outflow obstructive symptoms)
**# '''<span style="color:#ff0000">Large (>60 cc) prostate </span><span style="color:#0000ff">S</span><span style="color:#ff0000">ize for brachytherapy''' (increased risk of urinary side effects)
**# '''<span style="color:#0000ff">I</span><span style="color:#ff0000">nflammatory bowel disease</span>''' (increased risk for treatment-related morbidity)
**# '''<span style="color:#ff0000">History of prior pelvic </span><span style="color:#0000ff">R</span><span style="color:#ff0000">adiotherapy</span>''' (increased risk for treatment-related morbidity)