Editing Evaluation and Management of Erectile Dysfunction (section)

=== Hormonal therapy in patients with hypogonadism ===
* '''Testosterone monotherapy'''
** Unlikely leads to a clinically significant improvement in erectile function
*** Meta-analysis found that testosterone monotherapy increases IIEF-EF score by 2.65 compared to placebo§
** '''Not recommended for the purpose of treating ED in patients with hypogonadism and ED'''
* '''Dual PDE5i and testosterone therapy'''
** Some evidence to supports its use as a combination therapy to salvage patients who have failed PDE5is
** '''Should be considered in patients with hypogonadism and ED'''
*** '''Current recommendations suggest that a short (e.g. 3-month) therapeutic trial of testosterone is justified in men with hypogonadism, and in the absence of a response, testosterone administration should be discontinued'''
*** Once treatment with exogenous testosterone is initiated, ongoing follow-up is mandatory.
** Alternative hormonal replacement therapies have been suggested, but because of insufficient evidence they are not currently recommended for use