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===== UrologySchool.com Summary of non-surgical interventions for Peyronie's Disease ===== * '''Treatment depends on whether the patient’s symptoms are active (dynamic) vs. stable''' *'''<span style="color:#ff0000">AUA:</span>''' ** '''<span style="color:#ff0000">Recommended:</span>''' *** '''<span style="color:#ff0000">Active phase (1):</span>''' ***#'''<span style="color:#ff0000">NSAIDs for pain</span>''' *** '''<span style="color:#ff0000">Stable phase (2):</span>''' ***#'''<span style="color:#ff0000">Penile traction</span>''' ***#'''<span style="color:#ff0000">Intralesional (collagenase, verapamil, interferon alfa-2b) injection with modelling</span>''' ** '''<span style="color:#ff0000">Conditional (1):</span>''' **#'''<span style="color:#ff0000">Extracorporeal shockwave therapy for pain</span>''' **#* Recommendation is Conditional because the broader PD literature indicates that pain is the PD symptom that is most likely to resolve over time without intervention, the patient burden involved in obtaining ESWT treatment to treat pain may be substantial, and other treatments may be equally effective at alleviating pain. Further, ESWT is associated with frequent adverse events * '''<span style="color:#ff0000">CUA </span>(mostly similar to AUA, except CUA lists some oral medications that may be considered while these are not supported by AUA):''' ** '''<span style="color:#ff0000">Recommended:</span>''' *** '''<span style="color:#ff0000">Active phase: NSAIDs for pain</span>''' *** '''<span style="color:#ff0000">Stable phase: penile traction, intralesional treatment with modelling</span>''' '''(first-line: collagenase; second-line: verapamil or interferon where cost or concern related to adverse events limits use of collagenase; AUA does not use similar hierarchy of preferred treatments)''' ** '''<span style="color:#ff0000">May be considered:</span>''' *** '''<span style="color:#ff0000">Oral medication (alone or as a part of multimodal care) (different than AUA):</span>''' **** '''<span style="color:#0000ff">Can Consider Peyronie's Pills (4)</span>''' ***# '''<span style="color:#0000ff">C</span><span style="color:#ff0000">olchicine</span>''' ***# '''<span style="color:#0000ff">C</span><span style="color:#ff0000">o-enzyme Q10</span>''' ***# '''<span style="color:#0000ff">P</span><span style="color:#ff0000">otassium paraaminobenzoate</span>''' ***# '''<span style="color:#0000ff">P</span><span style="color:#ff0000">entoxifylline</span>''' *** '''<span style="color:#ff0000">Extracorporeal shockwave therapy for pain</span>'''
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