Editing Testosterone Deficiency (2018) (section)

===== Potential Harms (5) =====
# '''<span style="color:#ff0000">Polycythemia'''
# '''<span style="color:#ff0000">Increased prostate size'''
#* Studies have shown a '''significant increase in prostate volume''' during the first 6 months of treatment. However, the increase in prostate volume '''did not translate into worsening LUTS'''.
# '''<span style="color:#ff0000">Sleep apnea'''
# '''<span style="color:#ff0000">Gynecomastia</span>''' '''is a rare complication after TT'''
# '''<span style="color:#ff0000">Infertility'''
#*'''Exogenous testosterone therapy should not be prescribed to men who are currently trying to conceive'''
#**Exogenous testosterone therapy has been shown to interrupt normal spermatogenesis and can put patients in severely oligospermic or azoospermic states
#**While the vast majority of healthy men with normal testosterone levels will recover sperm production after cessation of exogenous testosterone, there are no high-quality reports detailing the recovery of spermatogenesis for either testosterone deficient or infertile males who have used exogenous testosterone.
#**'''For men already on exogenous testosterone who are planning future reproduction, testosterone cessation should occur in advance of initiation of any effort to conceive.''' '''Patients need to be made aware of the highly variable time course to recover sperm in the ejaculate and the variable degree to which spermatogenesis returns after stopping exogenous testosterone.'''
#***'''While two-thirds of males in contraceptive studies recovered sperm in the ejaculate within 6 months of exogenous testosterone therapy cessation, 10% failed to do so until the second year.'''
#***'''Some infertile men may never recover spermatogenesis after use of exogenous testosterone, and this important risk needs to be discussed with patients before starting treatment.'''