Editing Management of Localized and Locally Advanced Disease (section)

==== Recurrence following treatment ====
* '''Diagnosis of local recurrence after TA can be challenging''' because evolving fibrosis within the tumor bed can be difficult to differentiate from residual cancer.
* '''<span style="color:#ff0000">Findings suggestive of local recurrence (5):</span>'''
*# '''<span style="color:#ff0000">Enhancement within the tumor bed beyond 6 months</span>'''
*# '''<span style="color:#ff0000">Progressive increase in size of an ablated neoplasm</span>'''
*# '''<span style="color:#ff0000">New nodularity in or around the treated zone</span>'''
*# '''<span style="color:#ff0000">Failure of the treated lesion to regress over time</span>'''
*# '''<span style="color:#ff0000">Satellite or port site lesions</span>'''
* '''<span style="color:#ff0000">Most local recurrences can be salvaged with repeat ablation</span>'''
** Some patients with progressive disease eventually require conventional surgery.
*** PN and minimally invasive approaches are occasionally precluded in this setting because of the extensive fibrotic reaction induced by TA, necessitating RN.