Editing Peyronie's Disease (section)

===== Not effective =====
* '''Topical agents'''
** No topically applied agent (e.g. verapamil gel) has been shown to be effective in the treatment of PD
* '''Transdermal drug delivery''' with verapamil or dexamethosone using electromotive technology
** Was proposed to be superior to oral or injection therapy because it bypasses hepatic metabolism and minimizes the pain of inject. This approach has limited evidence of benefit
* '''Vacuum therapy'''
** Safe but unlikely to be of benefit due to short-term duration of stretching forces
* '''Radiation'''
** Should be avoided because of potential risk of malignant change and increase in the risk of ED in aging patients