Editing AUA: Early Detection of Prostate Cancer (2023) (section)

=== Germline mutations ===
* '''<span style="color:#ff0000">Breast Cancer Genes (BRCA)</span>'''
**'''<span style="color:#ff0000">BRCA1 and BRCA2 variants have increased risks of both prostate cancer onset and progression.</span>'''
*** '''<span style="color:#ff0000">Stronger association between BRCA2 and aggressive cancer</span>'''
***'''Systematic PSA screening is indicated'''
**'''<span style="color:#ff0000">Associated cancers (5): [https://www.ncbi.nlm.nih.gov/books/NBK1247/]</span>'''
**#<span style="color:#ff0000">'''Breast (male and female)'''</span>
**#<span style="color:#ff0000">'''Ovarian'''</span>
**#<span style="color:#ff0000">'''Prostate'''</span>
**#<span style="color:#ff0000">'''Pancreatic'''</span>
**#<span style="color:#ff0000">'''Melanoma'''</span>
* '''<span style="color:#ff0000">Other mutations</span>'''
**'''<span style="color:#ff0000">ATM, MLH1, MSH2, MSH6, PMS2, HOXB13, NBS1, and CHEK2</span>''' 
***These mutations need further study to evaluate their role in prostate cancer incidence and aggressiveness