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=== Penile Lymphatics === *'''<span style="color:#ff0000">Superficial lymphatic system</span>''' **'''<span style="color:#ff0000">Drains the prepuce and skin of the penile shaft</span>''' **'''<span style="color:#ff0000">Empties into the right and left superficial inguinal nodes</span>''' *'''<span style="color:#ff0000">Deep lymphatic system</span>''' **'''<span style="color:#ff0000">Drains the glans penis</span>''' **'''<span style="color:#ff0000">Empties into the superficial inguinal nodes and the deep inguinal nodes</span>''' *'''Primary site of metastatic spread of penile carcinoma occurs via the regional lymphatic system, first to the inguinal lymph node chain and then to the iliac and pelvic lymph nodes.''' ** '''Penetration of Buckβs fascia or the tunica albuginea by the primary penile tumor allows for dissemination of tumor cells into the lymphatic system''' **Presence and extent of regional LN metastases is the single most important prognostic factor in determining the long-term survival of patients with penile cancer ***If cancer has spread to the pelvic nodes, long-term survival is < 10% **'''Inguinal metastatic spread can be unilateral or bilateral''' ***Crossover drainage from the right to left groin or vice versa can also occur **Metastatic spread from the inguinal lymph nodes to the contralateral pelvis or from the right to left pelvis has never been reported. **'''Skip lesions with direct lymphatic drainage from penile tumors to the pelvic lymph nodes has never been reported.''' **Further spread from the true pelvis to the retroperitoneal lymph nodes is beyond the regional drainage system of the penis and represents systemic metastatic disease
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