Editing Prostate Cancer: Epidemiology and Pathogenesis (section)

=== Mortality ===
* '''<span style="color:#ff0000">US</span>'''
**Estimated mortality 2023: 34,700'''[https://acsjournals.onlinelibrary.wiley.com/doi/full/10.3322/caac.21763]'''
***'''<span style="color:#ff0000">Second most common cause of cancer-related death</span>'''
****Lung and bronchus cancer are most common cause of cancer-related death
***'''<span style="color:#ff0000">Cause of death in ≈3% of US men</span>'''
**** '''Only ≈16% of males diagnosed with prostate cancer ultimately die of it,''' demonstrating the indolent course of most prostate cancers
**** '''Most common cause of mortality in males with prostate cancer is cardiac disease'''[https://pubmed.ncbi.nlm.nih.gov/23795786/]
* '''Trends in Mortality'''
** '''Decreasing since 2001'''
* Average age of death from prostate cancer is 77 years
* Mortality in African-Americans 2.4x higher than Caucasians
'''Trends in stage'''
* There has been clinical and pathological stage migration over time largely due to PSA screening
* At the time of diagnosis[https://seer.cancer.gov/archive/csr/1975_2014/browse_csr.php?sectionSEL=23&pageSEL=sect_23_table.08.html#table3]
** ≈'''80% present with localized disease'''
** ≈12% present with regional disease
** ≈ 5% present with metastatic disease