Editing Management of Localized and Locally Advanced Disease (section)

==== Advantages/Disadvantages ====
*'''<span style="color:#ff0000">Advantage (1):</span>'''
*# '''<span style="color:#ff0000">Preserved renal function compared to RN</span>'''
* '''<span style="color:#ff0000">Disadvantages</span>'''
*# '''<span style="color:#ff0000">Higher risk of blood transfusions and urologic complications (e.g. urine leak) than TA or RN</span>'''
*#* A small proportion of patients to additional treatments (e.g. ureteral stents, abdominal drains, embolization of pseudoaneurysm).
*# '''<span style="color:#ff0000">Potential for hyperfiltration renal injury</span>'''
*#* Patients who undergo nephron-sparing surgery for RCC may be left with a relatively small amount of renal tissue and are at risk for development of long-term renal functional impairment from hyperfiltration renal injury
*#** '''<span style="color:#ff0000">Proteinuria is the initial manifestation</span>'''
*#*** '''<span style="color:#ff0000">A 24-hour urinary protein measurement should be obtained yearly in patients with a solitary remnant kidney to screen for hyperfiltration nephropathy</span>'''
*#** '''<span style="color:#ff0000">Efforts to prevent or to ameliorate the damaging effects of hyperfiltration</span>''' have focused on dietary and pharmacologic interventions, primarily the use of '''<span style="color:#ff0000">ACE-inhibitors combined with a low-protein diet</span>'''