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Muscle-Invasive Bladder Cancer
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===== Evidence ===== * No single phase III trial has demonstrated an overall survival benefit with AC compared to observation * '''2014 meta-analysis''' of 9 trials involving 945 patients '''comparing AC to standard of care found a 9% absolute survival benefit at 3 years.''' However, there were major deficiencies in the trials included such as small sample sizes, early closure of trials, limitations in statistical analysis, and differences in the way disease-free survival was defined. ** [https://pubmed.ncbi.nlm.nih.gov/24018020/ Leow, Jeffrey J., et al.] "Adjuvant chemotherapy for invasive bladder cancer: a 2013 updated systematic review and meta-analysis of randomized trials." European urology 66.1 (2014): 42-54.
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