Editing Hormonal Therapy (section)

=== Cognitive dysfunction ===

* '''ADT in men with PCa may be associated with (3):'''
*# '''Changes in cognition''' (concentration, memory)
*# '''Depression'''
*# '''Dementia'''
** '''Evidence related to causality remains weak and further prospective data are needed'''
** Changes in cognition
*** Conflicting findings
**** Some studies find reduced cognition
**** Self-reported changes in concentration, information processing, verbal fluency, visual information processing, visuospatial function, memory, and executive function, neuro-fatigue and apathy
**** Objective changes in verbal memory, spatial abilities and attention
**** Some studies find no change in cognition
**** One study reported improvement in episodic memory and delayed recall§
** Depression
*** Meta-analysis of 6 studies comprising 226,871 patients found significantly increased risk (HR 1.51 (95% CI 1.34 – 1.69))§
** Dementia
*** Meta-analysis of 9 studies comprising 442,665 patients found significantly increased risk (HR 1.21 (95% CI 1.11 – 1.33))§
** Alzheimer’s disease
*** Meta-analysis of 8 studies comprising 1,597,546 patients found significantly increased risk (HR 1.16 (95% CI 1.09 – 1.24))§