Editing Management of Localized and Locally Advanced Disease (section)

==== <span style="color:#ff0000">Indications</span> ====
* '''<span style="color:#ff0000">[https://pubmed.ncbi.nlm.nih.gov/28479239/ 2021 AUA Guidelines on Renal Mass and Localized Renal Cancer]:</span>'''
*# '''<span style="color:#ff0000">Consider for solid or Bosniak 3/4 complex cystic renal mass whenever increased oncologic potential is suggested</span>''' by tumor size, biopsy, and/or imaging characteristics
*## '''<span style="color:#ff0000">In this setting, RN is preferred If ALL criteria are met (3):</span>'''
*###'''<span style="color:#ff0000">High tumor complexity and PN would be challenging even in experienced hands</span>'''
*###'''<span style="color:#ff0000">No pre-existing CKD or proteinuria</span>'''
*### '''<span style="color:#ff0000">Normal contralateral kidney and new baseline eGFR will likely be > 45 mL/min/1.73m2 even if RN is performed</span>'''
*##*'''<span style="color:#ff0000">If ALL are not met, PN should be considered</span>''' unless there are overriding concerns about the safety or oncologic efficacy of PN.