Editing Functional: Pharmacological Management of LUTS (section)

===== Mechanism of action =====

*'''<span style="color:#ff0000">5α-reductase converts testosterone to DHT</span>'''
** '''<span style="color:#ff0000">Type 1 5α-reductase is expressed primarily in the non-genital skin and liver, and to a lesser extent in the prostate, testis, and brain</span>'''
** '''<span style="color:#ff0000">Type 2 5α-reductase is expressed predominantly in the prostate epithelium and other genital tissues such as the epididymis, genitalia, seminal vesicle, testis, but also in liver, uterus, breast, hair follicles, and placenta</span>'''
** '''<span style="color:#ff0000">Finasteride inhibits type 2, dutasteride inhibits both type 1 and 2</span>'''