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=== Clinical staging === * '''<span style="color:#ff0000">Prognosis of GCT and initial management decisions are determined by clinical stage (CS)''' * '''<span style="color:#ff0000">Based on (3):''' *# '''<span style="color:#ff0000">Pathologic stage of the primary tumour (pT stage)''' *# '''<span style="color:#ff0000">Presence and extent of regional (N stage) and distant metastatic disease (M stage)''' *# '''<span style="color:#ff0000">Post-orchiectomy serum tumor marker levels (S stage)''' *#* Serum tumor markers (AFP, hCG, and LDH) should be repeated at appropriate T1/2 time intervals after orchiectomy to determine nadir for staging and risk stratification *#** For patients with elevated AFP or hCG post-orchiectomy, clinicians should monitor serum tumor markers to establish nadir levels before treatment only if marker nadir levels would influence treatment. * '''Testicular cancer clinical stage groups''' {| class="wikitable" |Stage grouping | | | | |- |Stage 0 |pTis |N0 |M0 |S0 |- |Stage I |pT1-T4 |N0 |M0 |SX |- |Stage IA |pT1 |N0 |M0 |S0 |- |Stage IB |pT2 - pT4 |N0 |M0 |S0 |- |Stage IS |Any pT/TX |N0 |M0 |S1-3 |- |Stage II |Any pT/TX |N1-N3 |M0 |SX |- | rowspan="2" |Stage IIA |Any pT/TX |N1 |M0 |S0 |- |Any pT/TX |N1 |M0 |S1 |- | rowspan="2" |Stage IIB |Any pT/TX |N2 |M0 |S0 |- |Any pT/TX |N2 |M0 |S1 |- | rowspan="2" |Stage IIC |Any pT/TX |N3 |M0 |S0 |- |Any pT/TX |N3 |M0 |S1 |- |Stage III |Any pT/TX |Any N |M1a |SX |- | rowspan="2" |Stage IIIA |Any pT/TX |Any N |M1a |S0 |- |Any pT/TX |Any N |M1a |S1 |- | rowspan="2" |Stage IIIB |Any pT/TX |N1-N3 |M0 |S2 |- |Any pT/TX |Any N |M1a |S2 |- | rowspan="3" |Stage IIIC |Any pT/TX |N1-N3 |M0 |S3 |- |Any pT/TX |Any N |M1a |S3 |- |Any pT/TX |Any N |M1b |Any S |} * '''<span style="color:#ff0000">Overview of clinical staging:</span>''' ** '''<span style="color:#ff0000">Clinical stage (CS) I: disease confined to the testis</span>''' ** '''<span style="color:#ff0000">CS II: presence of regional (retroperitoneal) lymph node metastasis</span>''' ** '''<span style="color:#ff0000">CS III: non-regional lymph node and/or visceral metastasis, although post-orchiectomy serum tumour marker levels can upstage patients from CSII to CSIII</span>'''
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