Editing Prostate Cancer: Diagnosis and evaluation (section)

==== Stockholm-3 (STHLM-3) ====
*Multiplex test combining
**Clinical variables (age, first-degree family history of prostate cancer, and previous biopsy)
**Blood biomarkers (total PSA, free PSA, ratio of free to total PSA, hK2, MIC-1, and MSMB)
**Polygenic risk score (PRS)
*Has been evaluated as a first-line screening test for predicting the risk of GG2+ prostate cancers.[https://pubmed.ncbi.nlm.nih.gov/26563502/]
**STHLM-3 found to have a higher predictive accuracy compared to PSA alone (area under the curve [AUC] 0.74 versus 0.56) and reduced unnecessary biopsies by 32%
** Further validation in diverse populations to confirm these findings will be necessary to move forward into practice.