Editing Muscle-Invasive Bladder Cancer (section)

====== <span style="color:#ff00ff">SWOG S1011 (NEJM 2024)  ======
* Population: 592 patients with localized muscle-invasive bladder cancer of clinical stage T2 (confined to muscle) to T4a (invading adjacent organs) with two or fewer positive nodes (N0, N1, or N2) 
* Randomized to: bilateral standard lymphadenectomy (dissection of lymph nodes on both sides of the pelvis) or extended lymphadenectomy involving removal of common iliac, presciatic, and presacral nodes.
* Primary outcome: disease-free survival
* Results:
** Median follow-up: 6.1 years
** Disease-free survival: no significant difference
** Overall survival: no significant difference
** Extended lymphadenectomy was associated with higher perioperative morbidity and mortality
* Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer. Lerner et al. NEJM 2024.