Editing Functional: Pharmacological Management of LUTS (section)

==== Saw palmetto ====
* RCT
** 225 men age >49 with moderate-to-severe symptoms of benign prostatic hyperplasia
** Randomized to to one year of treatment with saw palmetto extract (160 mg twice a day) or placebo.
** Primary outcome: changes in the scores on the American Urological Association Symptom Index (AUASI) and the maximal urinary flow rate.
** Secondary outcome measures included changes in prostate size, residual urinary volume after voiding, quality of life, laboratory values, and the rate of reported adverse effects.
** Results
*** '''No significant difference between the saw palmetto and placebo groups in the change in AUASI scores, maximal urinary flow rate, prostate size, residual volume after voiding, quality of life, or serum prostate-specific antigen'''
** [https://pubmed.ncbi.nlm.nih.gov/16467543/ Bent, Stephen, et al."Saw palmetto for benign prostatic hyperplasia." New England Journal of Medicine 354.6 (2006): 557-566.]