Editing Upper Urinary Tract Urothelial Cancer (section)

====== Outcomes ======
* '''<span style="color:#ff00ff">Systematic review of endoscopic management of UTUC (2012)</span>'''
** Results:
*** Included 34 studies, 22 on URS and 12 on percutaneous resection
**** All were case series (level of evidence 4), or non-randomized comparative studies (level of evidence 3b)
*** Mean sample size
**** URS: 33
**** PCN: 24
**** 3 institutions for URS and 1 for PCN, have published outcomes on cohorts of ≥ 40 patients with > 50 months follow-up, limiting generalizability
*** Estimated 5-yr:
**** Recurrence-free survival: 13 – 54%
**** Renal preservation: 85%
**** Cancer-specific survival: 49-89%
**** OS 57-75%
**** Recurrence-free and cancer-specific survival outcomes worsened with increasing grade
*** [https://pubmed.ncbi.nlm.nih.gov/22471401/ Cutress, Mark L., et al. "Ureteroscopic and percutaneous management of upper tract urothelial carcinoma (UTUC): systematic review." ''BJU international'' 110.5 (2012): 614-628.]
* '''Given high risk of recurrence with endoscopic management, patients should be informed of the need for early second-look and stringent surveillance.'''