Editing Priapism (section)

=== Recurrent ischemic priapism ===
* Also known as "stuttering" priapism
*'''<span style="color:#ff0000">Definition: Recurrent ischemic episodes, with or without meeting the 4-hour time criteria for priapism</span>'''
**Unwanted painful erections occur repeatedly with intervening periods of detumescence
**The key differentiating factor between the current definition of recurrent ischemic priapism and other recurrent priapism-like conditions is the requirement of confirmed penile ischemia.
***Priapism-like conditions include sleep-related painful erections, undesired prolonged erections, and recurrent non-ischemic priapism
*'''Both acute ischemic priapism and non-ischemic priapism may recur over time'''
*'''<span style="color:#ff0000">Commonly associated with sickle cell disease</span>'''
** '''<span style="color:#ff0000">Priapism in children and adolescents is most commonly related to sickle cell disease</span>'''
*** The sickle cell genetic mutation is the result of a single amino acid substitution in the beta-globin subunit of hemoglobin S.
*** Clinical features seen in homozygous sickle cell disease: chronic hemolysis, vascular occlusion, tissue ischemia, and end-organ damage.
*** '''Sickle cell trait can be a predisposing factor to ischemic priapism.'''
** Pathogenesis is related to hemolysis and reduced nitric oxide
* '''<span style="color:#ff0000">Management focuses on</span>''' 
**'''<span style="color:#ff0000">Treatment of acute episodes</span>'''
**'''<span style="color:#ff0000">Prevention of future events</span>'''

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