Editing Prostate Cancer: Prevention (section)

=== <span style="color:#ff00ff">Selenium and Vitamin E Cancer Prevention Trial (SELECT) (JAMA 2009)</span> ===
* Objective: determine whether selenium, vitamin E, or combination thereof could reduce risk of prostate cancer
* Population: 35,533 men with normal DRE, PSA ≤ 4 ng/ml and normal blood pressure
* Randomized to 4 treatment arms: 
**Selenium + placebo
** Vitamin E + placebo
** Selenium + vitamin E
** Placebo + placebo
* Primary end point: biopsy-confirmed prostate cancer 
**Indications for biopsy not dictated by protocol
* Results: 
**Study planned for 12 years. '''Independent data and safety monitoring committee recommended discontinuation of the study because data convincingly demonstrated no effect'''
** '''Follow-up study showed that dietary supplementation with Vitamin E increased risk of prostate cancer'''
* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682779 Lippman, Scott M., et al.] "Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)." Jama 301.1 (2009): 39-51.