Editing EAU & ASCO: Penile Cancer 2023 (section)

=== Multimodal Chemotherapy/Radiotherapy in the management of regional lymph nodes ===

==== Chemotherapy ====

* Adjuvant chemotherapy
** Have a balanced discussion of risks and benefits with high-risk patients with surgically resected disease, in particular with those with pathological pelvic LN involvement (pN3)

==== Radiotherapy ====

* '''Adjuvant radiation (with or without chemo sensitisation)'''
** '''Indications'''
*** '''pN2/N3 disease (including those who received prior neoadjuvant chemotherapy)'''
* '''Definitive radiotherapy (with or without chemo sensitisation)'''
** '''Indications'''
*** '''Patients unwilling or unable to undergo surgery'''
*** '''cN3 patients who are not candidates for multi-agent chemotherapy'''