Editing Hormonal Therapy (section)

== Answers ==

# What are the current therapeutic approaches for androgen-axis blockade?
## Inhibit androgen synthesis
## Inhibition of androgen sources
## Inhibition of LHRH release
## Androgen-receptor blockade
# How long does it take to achieve castration levels of testosterone following bilateral orchiectomy?
#* 24 hours
# What are the advantages of LHRH antagonists over agonists?
#* No need for antiandrogen administration due to lack of LH surge with antagonists
#* Testosterone levels drop quickly
# What happens to LH and FSH levels after surgical castration? LHRH agonist? LHRH antagonist?
#* Surgical castration: elevated LH and FSH
#* LHRH agonist: suppressed LH, partially supressed FSH
#* LHRH antagonist: suppressed LH and FSH
# Compare the hormonal and toxicity profile of a steroidal to non-steroidal anti-androgens.
#* Steroidal: fluid retention, thromboembolism, hypogonadism; decreased LH and testosterone
#* Non-steroidal: liver toxicity, GI toxicity, gynecomastia and mastodynia; increased LH and testosterone
# What are the potential adverse effects associated with the use of enzalutamide? Abiteraterone? Apalutamide?
#* Enzalutamide: hypertension, fatigue, diarrhea, seizures, falls, fracture, hot flashes
#* Apalutamide: hypertension, fatigue, diarrhea, seizures, falls, fracture, hypothyroidism, rash, increased cholesterol, hyperglycemia, anemia
#* Abiraterone: hypertension, fatigue, fluid retention, hypokalemia, hepatotoxicity, myopathy and rhabdomyolysis, increased triglycerides and cholesterol
# What are the potential adverse effects associated with the use of ADT?
#* '''COACH Wants BDSM From Montreal'''
#* Cardiovascular disease
#* Osteoporosis
#* Anemia
#* Cognitive dysfunction
#* Hot flashes
#* Weight gain and % fat increase
#* Breast events
#* Diabetes
#* Sexual dysfunction
#* Muscle mass decrease
#* Fatigue
#* Metabolic