Editing Functional: Pharmacological Management of LUTS (section)

=== Alpha-blockers and anti-cholinergics ===
* Several RCTs have demonstrated that the '''combination treatment of anti-cholinergics and α1-blockers was more effective at reducing male LUTS''' '''than α1-blockers alone in men with OAB and coexisting bladder outlet obstruction'''
* '''α1-blockers and anti-cholinergics may have an additional synergistic effect on the bladder in the neurogenic population'''. This suggests that targeting multiple receptors may maximize the effectiveness of pharmacologic treatment of neurogenic bladder and should be considered in patients in whom treatment with antimuscarinics alone fails