Editing Germ Cell Tumours (section)

====== Relapse of seminoma ======

* '''If chemo-naïve:'''
** '''Patients relapsing on surveillance should receive primary radiotherapy'''
** '''Patients with CSI or II seminoma treated with radiotherapy, or those on surveillance that relapse with bulky''' (>3 cm) '''retroperitoneal masses and systemic relapse should receive first-line chemotherapy based on ICCCG risk category'''
*** Salvage rates approach 100%.
* '''If early relapse after chemotherapy: salvage chemotherapy'''
** An important consideration for patients with advanced seminoma who relapse after first-line chemotherapy is the potential for teratoma at the site of relapse.
** Patients with normal serum tumor markers should undergo biopsy before starting second-line chemotherapy'''.'''