Editing Disorders of Sexual Differentiation (section)

==== Female development ====
* '''Testosterone is not secreted by the ovaries and therefore the Wolffian ducts regress'''
** '''Wolffian duct remnants in the female (2):'''
**# '''Gartner duct'''
**#* '''Can form cysts near the vaginal introitus and anterolateral vaginal wall'''
**# '''Epoophoron and paroophoron: in the mesentery of the ovary'''
* '''Estrogen synthesis by the ovary is detectable in the female embryo just after 8 weeks of gestation.'''
** '''The rate-limiting enzyme is aromatase, which is higher in the fetal ovary than in the fetal testis.'''
* '''Estrogens are not required for normal female differentiation of the reproductive tract, but they can interfere with male differentiation.'''
** '''Estrogen can block the effect of AMH/MIS on Müllerian ducts'''
** '''Prenatal estrogen treatment of mothers has been associated with male reproductive tract abnormalities'''
* '''Because the ovary does not produce AMH/MIS, the Müllerian ducts are maintained and develop into the female internal reproductive tract (4):'''
*# '''Fallopian tubes'''
*# '''Uterus'''
*# '''Cervix'''
*# '''Proximal 2/3rd of the vagina'''
*#* '''The distal 1/3rd of the vagina is derived from the urogenital sinus'''
* '''In females and males with abnormalities in testosterone and/or DHT production, 5α-reductase deficiency, or androgen-receptor insufficiency, the primitive perineum does not lengthen and the'''
*# '''Genital tubercle bends inferiorly, passively become the clitoris'''
*# '''Urethral folds passively become the''' '''labia minora'''
*# '''Labioscrotal swellings passively become the labia majora'''
** '''The definitive urogenital sinus becomes the vestibule of the vagina'''
** '''5α-reductase deficiency more likely associated with ambiguous genitalia whereas complete androgen-receptor insufficiency have near-normal female external phenotype'''