Editing Non-Urothelial Bladder Cancer (section)

==Small cell==

* '''Type of neuroendocrine histology'''

===Epidemiology===
*Accounts for <1% of bladder cancer histology[https://pubmed.ncbi.nlm.nih.gov/2548704/]
===Management===
*'''Should be considered and treated as metastatic disease, even if there is no radiologic evidence of disease outside the bladder'''
* '''Even small components of small cell histology within urothelial carcinoma should be managed as small cell'''
*In general, primary small cell carcinoma of the bladder is '''very chemosensitive'''
*'''<span style="color:#ff0000">Should be treated with initial chemotherapy followed by radiation or cystectomy as consolidation, if even there is no metastatic disease</span>§'''
**'''Primary mode of therapy is chemoradiation therapy; chemotherapy and radical cystectomy is an option with similar survival''' (5-year CSS 16% chemoradiation vs. 18% chemotherapy and radical cystectomy)
*Primary method to improve survival will be more effective systemic therapy