Editing Upper Urinary Tract Urothelial Cancer (section)

====== Outcomes ======
*Largely dependent on clinicopathologic characteristics.
*'''<span style="color:#ff00ff">Systematic review and meta-analysis comparing nephron-sparing approach to radical nephroureterectomy (2016)</span>'''
** Primary outcome: cancer-specific survival
** Results
*** Included 22 studies published between 1999 and 2015
**** No RCTs comparing nephron-sparing approach and nephroureterectomy
*** High risk of bias across all domains analysed, limiting interpretation of comparisons
*** Segemental ureterectomy vs. RNU (10 studies): no significant difference in cancer-specific survival
*** Endoscopic vs. RNU
**** URS vs. RNU (5 studies): no significant difference in cancer-specific survival
***** Grade-based subgroup analyses found decreased cancer-specific survival in patients undergoing URS for high-grade disease
**** Percutaneous resection vs. RNU (2 studies): conflicting findings
** Seisen, Thomas, et al."Oncologic outcomes of kidney-sparing surgery versus radical nephroureterectomy for upper tract urothelial carcinoma: a systematic review by the EAU non-muscle invasive bladder cancer guidelines panel." ''European urology'' 70.6 (2016): 1052-1068.