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AUA: Early Detection of Prostate Cancer (2023)
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=== Age to start prostate cancer screening === *'''If age < 40, PSA screening is NOT recommended''' *'''<span style="color:#ff0000">If age > 40 and < 45</span>''' **'''<span style="color:#ff0000">Offer screening if at increased risk of developing prostate cancer based on (3):</span>''' **#'''<span style="color:#ff0000">Black ancestry</span>''' **#'''<span style="color:#ff0000">Germline mutations</span>''' **#'''<span style="color:#ff0000">"Strong" family history of prostate cancer</span>''' *'''<span style="color:#ff0000">If age >45-50, may begin prostate cancer screening and offer a baseline PSA test</span>''' **Change from 2018 guidelines which recommended screening if age 55-69 ***The 2023 guidelines describe that earlier initiation of screening is supported by observational studies that have demonstrated a prognostic value of obtaining a baseline PSA in early midlife ***The randomized trials that demonstrate a benefit for prostate cancer screening (Goteborg-1 and ERSPC) began at ages 50 and 55 years, respectively. **No randomized evidence showing a benefit to initiation of routine screening for prostate cancer before 45 years of age.
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