Editing Pathophysiology of Erectile Dysfunction (section)

===== Antihypertensive Agents =====
* '''Almost all antihypertensive drugs have ED listed as a potential side effect''', though recent well-designed controlled clinical trials have clarified their association with ED
* '''<span style="color:#ff0000">Associated with ED (3)</span>'''
*# '''<span style="color:#ff0000">α2-agonists (e.g. clonidine)</span>'''
*# '''<span style="color:#ff0000">Methyldopa (centrally acting antihypertensive agent)</span>'''
*#'''<span style="color:#ff0000">Diuretics</span>'''
*#* '''<span style="color:#ff0000">Spironolactone</span>''' is a nonselective mineralocorticoid receptor antagonist with moderate affinity for progesterone and androgen receptors. The latter property increases the likelihood of endocrine side effects, including loss of libido, gynecomastia, and impotence
*#*'''<span style="color:#ff0000">Thiazides (e.g. hydrochlorothiazide)'''
* '''<span style="color:#ff0000">Variably associated with ED</span>'''
** '''<span style="color:#ff0000">β-blockers</span>'''
*** '''<span style="color:#ff0000">Non-selective β antagonists (e.g. propranolol, labetalol) are associated with ED</span>'''
*** '''<span style="color:#ff0000">β1-selective antagonists (e.g. acebutolol, atenolol, bisoprolol, metoprolol, esmolol) are not associated with ED</span>'''
*'''<span style="color:#ff0000">Not associated with ED</span>'''
*# '''<span style="color:#ff0000">ACE-inhibitors</span>'''
*# '''<span style="color:#ff0000">ARBs</span>'''
*# '''<span style="color:#ff0000">α1-blockers</span>'''
*#* May cause retrograde ejaculation
*# '''<span style="color:#ff0000">Calcium channel blockers</span>'''
** '''ARBs and α-blockers may exert a positive effect of erectile function[https://onlinelibrary.wiley.com/doi/full/10.1111/j.1524-6175.2005.05285.x?sid=nlm%3Apubmed#t1 §]'''