Editing Pediatrics: Renal and Adrenal Oncology (section)

=== Pathology ===
* '''Shimada classification'''
** '''An age-linked histopathologic classification'''
** '''An important aspect is determining whether the tumor is stroma poor or stroma rich.'''
*** Subgroups of stroma-rich tumors (3):
***# Nodular
***# Intermixed
***# Well differentiated
**** Ganglioneuroma is a stroma-rich tumour
*** '''Subgroups of stroma-poor tumors (2)'''
***# '''Favorable'''
***# '''Unfavorable'''
**** '''Based on (3):'''
****# '''Age at diagnosis'''
****# '''Degree of histologic maturation'''
****# '''Mitotic rate'''
***** These histologic patterns are independently predictive of outcome.
****** '''Stroma-poor tumors with unfavorable histopathologic features have a very poor prognosis (< 10% survival)'''
* '''In situ neuroblastoma'''
** '''Small nodules of neuroblastoma cells found incidentally within the adrenal gland'''
** '''Histologically indistinguishable from neuroblastoma'''
** '''These small tumors regress spontaneously in most cases'''