Editing Peyronie's Disease (2015) (section)

==== Recommended ====
* '''Intralesional options (3):'''
*# '''Intralesional collagenase clostridium histolyticum and modeling''' by the physician and patient
*#* '''Used to reduce penile curvature; does NOT treat pain or ED'''
*#* '''Appropriate in patients with curvature >30° and <90° and intact erectile function (with or without the use of medications)'''
*#** '''To-date, clinical trials have not evaluated the use of collagenase in patients with hourglass deformity, ventral curvature, calcified plaque, or plaque located proximal to the base of the penis'''
*#** '''The magnitude of treatment effect beyond placebo is modest'''
*#* '''Potential adverse effects: penile bruising, pain, swelling, and corporal rupture'''
*# '''Intralesional Interferon α-2b'''
*#* '''Used to reduce curvature, plaque size, pain, and improve some vascular outcomes'''
*#* '''Appropriate in patients with curvature > 30° and without calcified plaque'''
*#** '''The magnitude of treatment effect beyond placebo is modest'''
*#* '''Potential adverse effects: sinusitis, flu-like symptoms, and minor penile swelling'''
*# '''Intralesional verapamil'''
*#* Evidence for the use of intralesional verapamil is weak
*#* '''Potential adverse effects: penile bruising, pain, dizziness, and nausea'''