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Pathophysiology of Erectile Dysfunction
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===== Psychotropics (antipsychotics, antidepressants, anxiolytics) ===== * '''Commonly produce sexual symptoms''' * '''SSRIs''' ** '''Up to 50% of patients experience increased sexual dysfunction''', mainly anorgasmia. *** Adverse effects can be modified by co-treatment with other drugs such as a PDE5 inhibitor or mianserin (atypical antidepressant). ** '''Differ in their ability to cause ED''' *** '''Paroxetine associated with higher rates of ED compared to citalopram''' * '''GABAergic drugs - inhibit erection''' * '''Tricyclics - orgasmic dysfunction and inhibit ejaculation''' * '''Monoamine oxidase inhibitors - orgasmic dysfunction''' * '''Benzodiazepines - higher rate of sexual dysfunction''' *'''<span style="color:#ff0000">Bupropion</span>''' ** '''A norepinephrine-dopamine reuptake inhibitor''' ** '''<span style="color:#ff0000">An alternative antidepressant that is not associated with ED</span>''' *** Addition of bupropion or a PDE5 inhibitor to an antidepressant seems to be an effective method to correct antidepressant-associated ED
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