Editing Prostate Cancer: Prevention (section)

== Answers ==

# Describe the PCPT trial

* Objective: determine whether a 5-ARI could reduce the risk of prostate cancer
* Design: Randomized 18,882 men aged ≥ 55 years with normal DRE and PSA ≤ 3.0ng/ml to finasteride 5mg or placebo daily for 7 years. Biopsy was recommended at the end of the study (7 years) for all participants, or “for cause” in men who had a PSA ≥ 4 ng/ml (adjusted for the effect of finasteride) or an abnormal DRE
* Primary end point: prevalence of prostate cancer during the 7 years of the study
* Results:
* Absolute risk reduction by finasteride: 6%
* Significant increase biopsy Gleason score 7-10 cancers in finasteride group