Editing CUA: Cystic Renal Lesions (2017)

'''See [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365391/ Original Guideline]'''

'''*****All information below contained in more inclusive [[Benign Kidney Tumours|Benign Renal Tumours]] Chapter Notes'''

== Bosniak Renal Cyst Classification ==

* '''<span style="color:#ff0000">If a complex cyst is first identified on US, contrast-enhanced axial imaging should be performed to better characterize the cyst</span>'''
* '''<span style="color:#ff0000">See </span>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365391/table/t1-cuaj-3-4-e66/ Table 1 from Original Guideline]'''
* '''<span style="color:#ff0000">Risk of malignancy</span>'''
** '''<span style="color:#ff0000">Bosniak II: 5%</span>,''' likely gross overestimation of the true risk, as most of the malignant category II lesions had features that made them too complex to be considered a true category II cyst
** '''<span style="color:#ff0000">Bosniak IIF: 8-27%</span>'''
** '''<span style="color:#ff0000">Bosniak III: 54%</span>'''
** '''<span style="color:#ff0000">Bosniak IV: 88%</span>, malignant until proven otherwise'''

== Intervention and follow-up ==

=== Bosniak I ===
* '''<span style="color:#ff0000">Follow-up for Bosniak I cysts is not warranted</span>'''
** Majority will grow over time; growth should not necessarily be considered a sign a malignancy
** Transformation into a more complex cyst is rare and has been reported in only a handful of cases
* '''<span style="color:#ff0000">Intervention is only warranted if the cyst becomes symptomatic''' (i.e., bleeding, recurrent infection or pain)
** Treatment options include: percutaneous management (aspiration +/- sclerotherapy) or surgery
** Percutaneous cyst decompression may also be considered prior to offering definitive treatment as a means to confirm that the source of symptoms are cyst-related.

=== Bosniak II ===
* '''<span style="color:#ff0000">Follow-up for Bosniak II cysts is not warranted</span>'''
* '''<span style="color:#ff0000">Intervention is only warranted if the cyst becomes symptomatic</span>'''

=== Bosniak IIF ===
* '''≈15% of these category IIF cysts will progress in complexity (to Bosniak category III or IV)''' over time
* '''<span style="color:#ff0000">Should be followed with a contrast-enhanced CT scan or MRI every 6 months for the first year. Cases without progression should be followed annually for at least 5 years.</span>'''

=== Bosniak III ===
* '''<span style="color:#ff0000">Surgical excision is generally suggested</span>'''
** '''Given the low metastatic potential of cystic RCC, the panel feels that reduced surgical margins and controlled cyst decompression (if required) can be performed with low risk of tumour recurrence.'''
** '''Likewise, due to the same reason, active surveillance and thermal-ablation therapies may also be considered as appropriate treatment alternatives in select cases'''

=== Bosniak IV ===
* '''<span style="color:#ff0000">Surgical excision is generally suggested</span>'''
** '''Most of these malignant cysts are thought to have low metastatic potential and thus, more conservative management may be safely considered in select cases'''

== Role of active surveillance for suspected cystic RCC ==

* '''The vast majority of cystic RCCs are multilocular cystic RCCs (mcRCC,)''' but all RCC subtypes may present in a predominantly cystic form. '''Cystic RCCs need to be distinguished from solid renal masses with necrotic components, which behave more aggressively.'''
* '''mcRCCs have consistently better cancer-specific and overall survival compared with solid RCCs.'''
** '''There is yet to be a report demonstrating metastases or recurrence of mcRCCs.''' To reflect this indolent behaviour, the International Society of Urological Pathology (ISUP) has recently modified its terminology and now recommends calling these lesions multilocular cystic renal neoplasm with low malignant potential.
** One potential explanation for this better prognosis is that the majority of mcRCCs tumour volume is fluid and thus, the actual tumour burden is much lower when compared to similar sized solid tumours. As the outcomes of these tumours do not seem to be influenced by the overall lesion size, some experts have even suggested to abandon the current pathological T staging for mcRCC and to reassigned them a new stage called pT1c (c for cystic).
* '''Given their relatively indolent nature, there is emerging evidence suggesting that these lesions (especially Bosniak classification III) can be safely managed by active surveillance.''' If active surveillance is considered, it seems reasonable to follow these lesions with abdominal imaging every 6 months for the first 2 years, followed by yearly imaging thereafter, if the lesion is stable.
* '''Triggers for interventions are yet to be clearly defined and validated, but may include:'''
*# '''Progression from Bosniak III to IV'''
*# '''Growth of solid nodule > 3 cm'''
*# '''Fast-growing nodule'''

== Thermal-ablation therapies ==

* '''Given the limited data, RFA should be limited to patients with small Bosniak category III and IV cysts who are poor operative candidates and in whom active surveillance is not being considered'''
* '''The role of cryotherapy in the management of Bosniak III or IV cysts is not well-defined,''' with only a handful of cases reported to have been treated by the approach in the literature.

== Role of renal tumour biopsy in the management of cystic lesions ==

* There is evidence that RTBs are significantly less informative for the diagnosis of cystic lesions than for solid ones.
* '''It is generally felt that RTB is not diagnostic for most Bosniak III cysts, as there is minimal targetable solid component.'''
* '''For Bosniak IV cysts, a biopsy of the solid component may be considered to confirm the presence of a malignant tumour and to help with decision-making in select cases (elderly, multiple comorbidities, unfit for treatment, etc).'''