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| **'''<span style="color:#ff0000">Treat for 2 weeks duration</span>''' | | **'''<span style="color:#ff0000">Treat for 2 weeks duration</span>''' |
| *'''<span style="color:#ff0000">Therapy is initially with parenteral antibiotics (depending on the severity of the infection) followed by oral antibiotics with wide-spectrum antimicrobial activity</span>''' | | *'''<span style="color:#ff0000">Therapy is initially with parenteral antibiotics (depending on the severity of the infection) followed by oral antibiotics with wide-spectrum antimicrobial activity</span>''' |
| ** '''The most common drugs suggested for initial therapy are a combination of penicillin (i.e., ampicillin) and an aminoglycoside (i.e., gentamicin), second- or third-generation cephalosporins (i.e. ceftriaxone), or one of the fluoroquinolones.'''
| | * '''<span style="color:#ff0000">In patients with acute prostatitis with ESBL or suspected ESBL organisms (usually associated with transrectal prostate biopsies), treatment with a carbapenem (ertapenem, imipenem, or meropenem),</span>''' amikacin, or colistin '''for at least 10 to 14 days is recommended''' |
| *** This traditional approach has changed recently because of the increasing risk of post–prostate biopsy prostate infection with ESBL microorganisms
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| *** In acute bacterial prostatitis that result from previous manipulation of the lower urinary tract (including prostate biopsy), the organisms show different patterns of virulence and resistance (e.g., to quinolones and cephalosporins) compared with the organisms associated with spontaneous acute prostatitis
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| ** '''<span style="color:#ff0000">In patients with acute prostatitis with ESBL or suspected ESBL organisms (usually associated with transrectal prostate biopsies), treatment with a carbapenem (ertapenem, imipenem, or meropenem),</span>''' amikacin, or colistin '''for at least 10 to 14 days is recommended'''
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| * '''<span style="color:#ff0000">Once the acute infection has settled down, therapy should be continued with one of the oral antimicrobial agents</span> appropriate for the treatment of chronic bacterial prostatitis''' (e.g., trimethoprim or fluoroquinolones or ESBL-effective antimicrobial therapy based on sensitivity analysis). '''The duration of optimal therapy is unknown; <span style="color:#ff0000">between 2 and 4 weeks has been suggested</span>'''
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| ==== '''<span style="color:#ff0000">CPPS</span>''' ==== | | ==== '''<span style="color:#ff0000">CPPS</span>''' ==== |