Hypercortisolism: Difference between revisions
Urology4all (talk | contribs) Created page with "== Hypothalamus-Pituitary-Adrenal (HPA) Axis == * '''Hypothalamus''' ** '''Produces corticotropin-releasing hormone (CRH)''' * '''Corticotropin-releasing hormone (CRH)''' ** '''Function:''' *** '''Acts on the corticotropic cells of the anterior pituitary to make ACTH''' ** '''Secretion''' *** Under tight control of the hypothalamic suprachiasmatic nucleus *** '''Follows circadian patterns.''' **** '''The highest level of cortisol in healthy subjects is detected in the m..." |
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*** '''High-dose dexamethasone suppression testing was used in the past''' to differentiate pituitary and ectopic ACTH sources, but the value of the test is limited. | *** '''High-dose dexamethasone suppression testing was used in the past''' to differentiate pituitary and ectopic ACTH sources, but the value of the test is limited. | ||
**** The study is based on the principle that high enough doses of dexamethasone should suppress ACTH production by pituitary adenomas, whereas ectopic ACTH production continues despite the high-dose glucocorticoid administration | **** The study is based on the principle that high enough doses of dexamethasone should suppress ACTH production by pituitary adenomas, whereas ectopic ACTH production continues despite the high-dose glucocorticoid administration | ||
[[File:Hypercortisolism.jpg|thumb]] | |||
== Management == | == Management == | ||