Adrenal: Malignant Tumours: Difference between revisions

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 * '''Multimodal treatment, surgical resection, radiation therapy, and systemic chemotherapy are often necessary'''
-* '''Mitotane,''' an oral synthetic derivative of the insecticide dichlorodiphenyltrichloroethane (DDT), '''is the most commonly used chemotherapeutic agent in the treatment of ACC'''
+* '''Systemic chemotherapy'''
-** '''Mitotane inhibits several enzymes of the adrenal cortex including the cholesterol side-chain cleavage enzyme''' (P450scc, CYP11A1), '''11β-hydroxylase''' (CYP11B1), '''18-hydroxylase''' (aldosterone synthase, CYP11B2), and 3β-hydroxysteroid dehydrogenase (3β-HSD) to a lesser extent
+**'''Mitotane'''
+***Oral synthetic derivative of the insecticide dichlorodiphenyltrichloroethane (DDT)
+***Mechanism of action: '''inhibits several enzymes of the adrenal cortex including the cholesterol side-chain cleavage enzyme''' (P450scc, CYP11A1), '''11β-hydroxylase''' (CYP11B1), '''18-hydroxylase''' (aldosterone synthase, CYP11B2), and 3β-hydroxysteroid dehydrogenase (3β-HSD) to a lesser extent
+***'''Most commonly used chemotherapeutic agent in the treatment of adrenal cortical carcinoma'''
 === Prognosis ===