Penile Cancer: Squamous Penile Cancer: Difference between revisions
Urology4all (talk | contribs) |
Urology4all (talk | contribs) |
||
| Line 307: | Line 307: | ||
* '''<span style="color:#ff0000">Lymph node involvement is most important prognostic factor for survival</span>''' | * '''<span style="color:#ff0000">Lymph node involvement is most important prognostic factor for survival</span>''' | ||
** 5-year survival: lymph node involvement vs. without: 73% vs. 60% (range 0-86% depending on extent of lymph node involvement) | ** 5-year survival: lymph node involvement vs. without: 73% vs. 60% (range 0-86% depending on extent of lymph node involvement) | ||
* '''Clinically negative groins''' | * '''<span style="color:#ff0000">Clinically negative groins</span>''' | ||
** '''<span style="color:#ff0000">≈20% of patients with clinically nonpalpable inguinal nodes harbor occult metastases</span>''' | ** '''<span style="color:#ff0000">≈20% of patients with clinically nonpalpable inguinal nodes harbor occult metastases</span>''' | ||
** '''Patients with stage ≥pT2 have high risk of metastasis, patients with pTis, pTa, pT1, grade 1 tumours have low risk of metastasis''' | ** '''Patients with stage ≥pT2 have high risk of metastasis, patients with pTis, pTa, pT1, grade 1 tumours have low risk of metastasis''' | ||
| Line 352: | Line 352: | ||
*** Palpable adenopathy in the context of verrucous carcinoma is very likely to be reactive and should be initially observed. Biopsy should be reserved unless the node remains persistently enlarged or grows over time. | *** Palpable adenopathy in the context of verrucous carcinoma is very likely to be reactive and should be initially observed. Biopsy should be reserved unless the node remains persistently enlarged or grows over time. | ||
*** '''Lymphadenectomy in the context of verrucous carcinoma should be reserved for cases of biopsy-proven metastases.''' | *** '''Lymphadenectomy in the context of verrucous carcinoma should be reserved for cases of biopsy-proven metastases.''' | ||
* '''Fixed inguinal lymph nodes (cN3)''' | * '''<span style="color:#ff0000">Fixed inguinal lymph nodes (cN3)</span>''' | ||
** '''Neoadjuvant chemotherapy followed by radical inguinal lymphadenectomy in responders''' | ** '''<span style="color:#ff0000">Neoadjuvant chemotherapy followed by radical inguinal lymphadenectomy in responders</span>''' | ||
* '''2018 EAU Penile Cancer Guidelines: Summary of treatment strategies for nodal metastases''' | * '''2018 EAU Penile Cancer Guidelines: Summary of treatment strategies for nodal metastases''' | ||