Pediatrics: Renal and Adrenal Oncology: Difference between revisions
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=== Genetics === | === Genetics === | ||
* '''Majority arise from somatic mutations''' restricted to tumor tissue; '''much smaller percentage originate from germline mutations''' | * '''<span style="color:#ff0000">Majority arise from somatic mutations</span>''' restricted to tumor tissue; '''much smaller percentage originate from germline mutations''' | ||
*'''Genes identified as having a role in the development of Wilms tumor (4): WT1''', 11p15, WTX, CTNNB1, TP53 | *'''Genes identified as having a role in the development of Wilms tumor (4): WT1''', 11p15, WTX, CTNNB1, TP53 | ||
** '''WT1''' | ** '''WT1''' | ||
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****'''Predispose patients to renal insufficiency''' | ****'''Predispose patients to renal insufficiency''' | ||
** '''WT1 mutations''' | ** '''WT1 mutations''' | ||
* '''Syndromes associated with Wilms tumours (4): B.W.’s Dick Feels Warm''' | * '''<span style="color:#ff0000">Syndromes associated with Wilms tumours (4):</span><span style="color:#0000ff"> B.W.’s Dick Feels Warm''' | ||
*#'''Beckwith-Weideman''' | *#'''<span style="color:#ff0000">Beckwith-Weideman''' | ||
*#'''Denys Drash''' | *#'''<span style="color:#ff0000">Denys Drash''' | ||
*#'''Frasier''' | *#'''<span style="color:#ff0000">Frasier''' | ||
*#'''WAGR''' | *#'''<span style="color:#ff0000">WAGR''' | ||
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