Landmark studies: Difference between revisions
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===== Immunotherapy ===== | ===== Immunotherapy ===== | ||
* CheckMate 274 NEJM 2021 (adjuvant nivolumab) | * [https://test.urologyschool.com/index.php/Muscle-Invasive_Bladder_Cancer#CheckMate_274_(adjuvant_nivolumab) CheckMate 274 NEJM 2021 (adjuvant nivolumab)] | ||
===== Cystectomy ===== | ===== Cystectomy ===== | ||
Revision as of 18:19, 17 March 2024
***This page is outdated***
Oncology
Prostate Cancer
Prevention
- PCPT 2003 (Finasteride)
- SELECT 2009 (Selenium and Vitamin E)
- REDUCE 2010 (Dutasteride)
Screening
- PLCO 2008
- ERSPC 2009
- Goteburg 2010
- CAP 2018
Diagnosis and Evalutation
- MRI PROMIS 2017
- PRECISION 2018
- MRI-FIRST 2019
- ASIST 2019 (MRI in AS)
- STHLM3 NEJM 2021 (MRI-targetted vs. standard biopsy in prostate cancer screening)
- PET proPSMA 2020
PSA and Other Markers
- Stamey et al. NEJM 1987
- Catalona et al. NEJM 1991
- Catalona et al. J Urol 1994 (PSA vs. DRE detection in screening)
- Catalona et al. 1998 (%fPSA)
Prostate Biopsy
- Antibiotic Prophylaxis in TRUS Biopsy of the Prostate Cochrane Review 2011
- Rates of hospital admission and mortality after TRUS-biopsy J Urol 2013
Management of Localized Disease
Observation vs. Treatment of Prostate Cancer
- PIVOT NEJM 2012
- SPCG-4 NEJM 2014
- PROTECT NEJM 2016
Active surveillance
- REDEEM Lancet 2012 (dutasteride in AS progression)
Radical prostatectomy
- Antibiotic prophylaxis at the time of catheter removal after radical prostatectomy
Radiation and ADT
- EORTC 22863 NEJM 1997 (EBRT +/- 3 years ADT)
- RTOG 86-10 (EBRT +/- 4 months ADT)
- RTOG 92-02
- EORTC 22961
- PR3/PR07
- SPCG-7/SFUO-3
Management of Locally Advanced Disease
Post-prostatectomy radiation
- ARTISTIC Lancet 2020 (meta-analysis of adjuvant vs. salvage) RADICALS Lancet 2020 (adjuvant vs. salvage)
Metastatic Hormone-Sensitive Prostate Cancer
- CHAARTED NEJM 2015 (docetaxel)
- STAMPEDE Lancet 2016 (docetaxel)
- STAMPEDE NEJM 2017 (abiraterone)
- LATITUDE NEJM 2017 (abiraterone)
- STAMPEDE Lancet 2018 (radiation)
- ENZAMET NEJM 2019 (enzalutamide)
- ARCHES JCO 2019 (enzalutamide)
- TITAN NEJM 2019 (enzalutamide)
Castrate-Resistant Prostate Cancer
Non-metastatic
- ARAMIS NEJM 2018 (darolutamide)
- SPARTAN NEJM 2018 (apalutamide)
- PROSPER NEJM 2018 (enzalutamide)
Metastatic
Pre-docetaxel
- AFFIRM NEJM 2012 (enzalutamide)
- PREVAIL NEJM 2014 (enzalutamide)
- COU-AA-302
- TAX-327
- IMPACT
Post-docetaxel
- COU-AA-301
- VISION (177Lu-PSMA-617)
- PROfound NEJM 2020 (Olaparib)
- Denosumab vs. zoledronate
- TheraP (177Lu-PSMA-617 vs. cabazitaxel)
- ALSYMPCA (Radium-223)
Incidence of germline mutations in genes mediating DNA-repair processes in prostate cancer NEJM 2016
Kidney Cancer
- EORTC 30904 Partial vs. Radical Nephrectomy
- EORTC 30811 Eur Urol 2009 LND for cN0 suspected RCC
Cytoreductive nephrectomy
- SWOG 8949 IFN-α vs. CN + IFN-α vs.
- EORTC 30947 IFN-α vs. CN + IFN-α
- SURTIME JAMA Onc 2019 CN + sunitnib vs. sunitnib + CN
- CARMENA NEJM 2018 sunitnib vs. CN + sunitnib
Systemic treatment for metastatic disease
- CheckMate 214 NEJM 2018 (nivolumab + ipilimumab vs. sunitnib for untreated, advanced clear-cell RCC)
- CheckMate 9ER NEJM 2020 (nivolumab + cabozantinib vs. sunitnib for untreated, advanced clear-cell RCC)
- CLEAR NEJM 2021 (lenvatinib + pembrolizumab vs. lenvatinib + everolimus vs. sunitinib)
Adjuvant therapy after nephrectomy
- ASSURE Lancet 2016 (sunitnib vs. sorafenib)
- S-TRAC (sunitnib)
- KEYNOTE-564 (pembrolizumab)
Bladder Cancer
NMIBC
Blue-light vs. white-light flexible cystoscopy in NMIBC surveillance 2018
Intravesical Therapy
Chemotherapy
- Meta-analysis of trials evaluating chemotherapy on risk of NMIBC recurrence 2013
BCG
- SWOG 8216/38 NEJM 1991 (BCG vs. doxorubicin BCG maintenance)
- SWOG 8507 J Urol 2000 (induction vs. induction + maintenance BCG)
- BCG and NMIBC Recurrence Cochrane Review 2000
- BCG and NMIBC Progression Meta-analaysis 2002
- BCG vs. MMC in NMIBC Cochrane Review 2003
BCG unresponsive NMIBC
- KEYNOTE-057 (pembrolizumab for BCG-unresponsive CIS)
MIBC
Neoadjuvant Chemotherapy
- SWOG 8710 NEJM 2003 (neoadjuvant MVAC)
- BA06 30894 JCO 2011 (neoadjuvant CMV)
Immunotherapy
Cystectomy
Systemic treatment for locally advanced, unresectable, or metastatic disease
- KEYNOTE-361 Lancet Onc 2021 (pembrolizumab + chemotherapy vs. chemotherapy alone vs. pembrolizumab alone)
Upper tract urothelial carcinoma
- Olympus Lancet Onc 2020 (UGN-101 for papillary UTUC)
Non-Oncology
Andrology
- Testosterone Deficiency
- TEAAM (Testosterone's Effects on Atherosclerosis Progression in Aging Men) JAMA 2015
- Peyronie's Disease
Functional
- TOMUS (retropubic vs. transobturator MUS)
- MTOPS (combination alpha-blocker + 5ARI)
- CombAT (combination alpha-blocker + 5ARI)
Pediatrics
- RIVUR NEJM 2014 (antibiotic prophylaxis in VUR)
Other
- Mechanical Bowel Preparation for Elective Colorectal Surgery Cochrane Review 2011