Germ Cell Tumours: Difference between revisions

Line 26:

* '''Established risk factors (5):'''

*# '''~~Cryptorchidism~~'''

**'''Inherited (3):'''

*~~#* '''Ipsilateral testis: relative risk 4-6x; relative risk decreases to 2-3x if orchidopexy is performed before puberty'''~~

**# '''Family history of GCT'''

*#* '''Contralateral testis: slightly increased risk''' (relative risk 1.74x)

**# '''Germ Cell Neoplasia In-Situ (GCNIS)'''

*# '''Family history of GCT'''

**#* Previously referred to as intratubular germ cell neoplasia (ITGCN) unclassified

*~~# '''Personal history of GCT'''~~

**#*'''All adult invasive GCTs arise from GCNIS, except spermatocytic seminoma.'''

*# '''Germ Cell Neoplasia In-Situ (GCNIS)~~, previously~~ referred to as intratubular germ cell neoplasia (ITGCN) unclassified~~'''~~

**#* Among males with GCNIS, the risk of developing invasive GCT is ≈50% at 5 years

*#* '''All adult invasive GCTs arise from GCNIS, except spermatocytic seminoma.'''

**#* '''GCNIS develops before birth from an arrested gonocyte'''

*#* Among males with GCNIS, the risk of developing invasive GCT is ≈50% at 5 years

**# '''Race'''

*#* '''GCNIS develops before birth from an arrested gonocyte'''

**#* '''Caucasian risk > African-American'''

*# '''Race'''

**'''Acquired (2):'''

*#* '''Caucasian risk > African-American'''

**#'''Cryptorchidism'''

**#* '''Ipsilateral testis: relative risk 4-6x; relative risk decreases to 2-3x if orchidopexy is performed before puberty'''

**#* '''Contralateral testis: slightly increased risk''' (relative risk 1.74x)

**#'''Personal history of GCT'''

== Genetics ==

@@ Line 26: / Line 26: @@
 * '''<span style="color:#ff0000">Established risk factors (5):</span>'''
-*# '''<span style="color:#ff0000">Cryptorchidism</span>'''
+**'''<span style="color:#ff0000">Inherited (3):</span>'''
-*#* '''Ipsilateral testis: relative risk 4-6x; relative risk decreases to 2-3x if orchidopexy is performed before puberty'''
+**# '''<span style="color:#ff0000">Family history of GCT</span>'''
-*#* '''Contralateral testis: slightly increased risk''' (relative risk 1.74x)
+**# '''<span style="color:#ff0000">Germ Cell Neoplasia In-Situ (GCNIS)</span>'''
-*# '''<span style="color:#ff0000">Family history of GCT</span>'''
+**#* Previously referred to as intratubular germ cell neoplasia (ITGCN) unclassified
-*# '''<span style="color:#ff0000">Personal history of GCT</span>'''
+**#*'''All adult invasive GCTs arise from GCNIS, except spermatocytic seminoma.'''
-*# '''<span style="color:#ff0000">Germ Cell Neoplasia In-Situ (GCNIS)</span>, previously referred to as intratubular germ cell neoplasia (ITGCN) unclassified'''
+**#* Among males with GCNIS, the risk of developing invasive GCT is ≈50% at 5 years
-*#* '''All adult invasive GCTs arise from GCNIS, except spermatocytic seminoma.'''
+**#* '''GCNIS develops before birth from an arrested gonocyte'''
-*#* Among males with GCNIS, the risk of developing invasive GCT is ≈50% at 5 years
+**# '''<span style="color:#ff0000">Race</span>'''
-*#* '''GCNIS develops before birth from an arrested gonocyte'''
+**#* '''Caucasian risk > African-American'''
-*# '''<span style="color:#ff0000">Race</span>'''
+**'''<span style="color:#ff0000">Acquired (2):</span>'''
-*#* '''Caucasian risk > African-American'''
+**#'''<span style="color:#ff0000">Cryptorchidism</span>'''
+**#* '''Ipsilateral testis: relative risk 4-6x; relative risk decreases to 2-3x if orchidopexy is performed before puberty'''
+**#* '''Contralateral testis: slightly increased risk''' (relative risk 1.74x)
+**#'''<span style="color:#ff0000">Personal history of GCT</span>'''
 == Genetics ==